Publications - Disease diagnosis

Novel interferon-gamma assays for diagnosing tuberculosis in young children in India

Post Date:

2017-04-01

Countries:

India

Clinical Sites:

BJGMC

Publication:

International Journal of Tuberculosis and Lung Disease

Setting: The tuberculin skin test (TST) and interferon-gamma release assays (IGRAs) are used as supportive evidence to diagnose active tuberculosis (TB). Novel IGRAs could improve diagnosis, but data are lacking in young children. Design: Children (age 5 years or...

Reducing uncertainty for acute febrile illness in resource-limited settings: the current diagnostic landscape

Post Date:

2017-03-27

Publication:

The American Journal of Tropical Medicine and Hygiene

After decades of slow progress in diagnostics for acute febrile illness in resource-limited settings, a wave of converging advancements will enable clinicians in resource limited settings to reduce uncertainty for the diagnosis of acute febrile illness.

Quantitative IFN-y,IL-2 response and latent tuberculosis test discordance in HIV-infected pregnant women

Post Date:

2016-06-15

Countries:

India

Clinical Sites:

BJGMC

Publication:

American Journal of Respiratory and Critical Care Medicine

Rationale: Pregnant women with latent tuberculosis infection (LTBI) are at high risk for development of TB, especially if infected with HIV. Objectives: To assess the performance of LTBI tests in pregnant and postpartum women infected with HIV, investigate the...

Next-generation sequencing in neuropathologic diagnosis of infections of the nervous system

Post Date:

2016-06-13

Publication:

Neurology, Neuroimmunology and Neuroinflammation

OBJECTIVE: To determine the feasibility of next-generation sequencing (NGS) microbiome approaches in the diagnosis of infectious disorders in brain or spinal cord biopsies in patients with suspected CNS infections. METHODS: In a...

Economic challenges associated with tuberculosis diagnostic development

Post Date:

2014-08-15

Publication:

Expert Review of Pharmacoeconomics and Outcomes Research

Tuberculosis remains a global health crisis in part due to underdiagnosis. Technological innovations are needed to improve diagnostic test accuracy and reduce the reliance on expensive laboratory infrastructure. However, there are significant economic challenges impeding the development and...

Cost-effectiveness of rapid susceptibility testing against second line drugs for tuberculosis

Post Date:

2014-06-15

Publication:

International Journal of Tuberculosis and Lung Disease

Background : Drug susceptibility testing (DST) against second-line tuberculosis drugs (SLDs) is essential for improving outcomes among multidrug-resistant (MDR-) and extensively drug-resistant tuberculosis (XDR-TB) cases. Objective : To evaluate the potential cost-...

Gender-related barriers and delays in accessing tuberculosis diagnostic and treatment services - Part 2: a systematic review of qualitative studies

Post Date:

2014-05-11

Publication:

Tuberculosis Research and Treatment

Background: Tuberculosis (TB) remains a significant global public health problem with known gender-related (male versus female) disparities. We reviewed the qualitative evidence (written/spoken narrative) for gender-related differences limiting TB service access from symptom onset to treatment...

Biomarkers for sepsis: a review with special attention to India

Post Date:

2014-03-19

Countries:

India

Publication:

BioMed Research International

Sepsis is a serious infection and still a common cause of morbidity and mortality in resource-limited settings such as India. Even when microbiologic diagnostics are available, bacteremia is only identified in a proportion of patients who present with sepsis and bloodstream infections...

Improving diagnostic capability for HPV disease internationally within the NIH-NIAID-Division of AIDS Clinical Trial Networks

Post Date:

2013-12-15

Countries:

India

Clinical Sites:

BJGMC

Publication:

American Journal of Clinical Pathology

OBJECTIVES: To evaluate an external quality assurance (EQA) program for the laboratory diagnosis of human papillomavirus (HPV) disease that was established to improve international research capability within the Division of AIDS at the National Institute of Allergy and...

Pediatric tuberculosis in young children in India: a prospective study

Post Date:

2013-11-11

Countries:

India

Clinical Sites:

BJGMC

Publication:

BioMed Research International

Background: India has one of the highest tuberculosis (TB) burdens globally. However, few studies have focused on TB in young children, a vulnerable population, where lack of early diagnosis results in poor outcomes. Methods: Young children (≤ 5 years) with...

Screening for pulmonary tuberculosis in HIV-infected individuals: AIDS Clinical Trials Group Protocol A5253

Post Date:

2013-04-15

Countries:

Clinical Sites:

Publication:

International Journal of Tuberculosis and Lung Disease

Background: Improved tuberculosis (TB) screening is urgently needed for human immunodeficiency virus (HIV) infected patients. Methods: An observational, multi-country, cross-sectional study of HIV-infected patients to compare a standardized diagnostic...

Tuberculosis in pregnant and postpartum women: Epidemiology, management, and research gaps

Post Date:

2012-12-15

Publication:

Clinical Infectious Diseases

Tuberculosis is most common during a woman's reproductive years and is a major cause of maternal-child mortality. National guidelines for screening and management vary widely owing to insufficient data. In this article, we review the available data on (1) the global burden of tuberculosis in...

Evaluation of a multimodal, distance learning HIV management course for clinical care providers in India

Post Date:

2012-10-01

Countries:

India

Publication:

Journal of the International Association of Providers of AIDS Care

Distance learning is an important tool for training HIV health workers. However, there is limited evidence on design and evaluation of distance learning HIV curricula and tools. We therefore designed, implemented, and evaluated a distance learning course on HIV management for clinical care...

Detection of microbial translocation in HIV and SIV infection using the limulus amebocyte lysate assay is masked by serum and plasma

Post Date:

2012-08-01

Countries:

Publication:

PLOS One

Objective: Microbial translocation (MT) is thought to be a major contributor to the pathogenesis of HIV-related immune activation, and circulating lipopolysaccharide (LPS) from Gram-negative bacteria is the principle measurement of this process. However, related research has been impeded by...

Authors’ response to Hanrahan et al CID article

Post Date:

2012-05-15

Countries:

India

Clinical Sites:

BJGMC

Publication:

Clinical Infectious Diseases

Reply to letter

Determination of a reference interval in a population

Post Date:

2012-02-01

Countries:

India

Publication:

National Medical Journal of India

The reference interval is the most widely used medical decision-making tool that separates healthy from diseased individuals. We briefly discuss the methods used to determine reference interval and its limitations.

Sexually transmitted infections and risk behaviors among transgender persons (Hijras) of Pune, India

Post Date:

2012-01-15

Countries:

India

Publication:

Journal of Acquired Immune Deficiency Syndromes

Background: The objectives of this cross-sectional study were to determine the prevalence of HIV and sexually transmitted infections (STI) in Hijras (self-identified transgenders of South Asia), study associated risk factors, and compare the prevalence with that in heterosexual men and men...

Building a global health education network for clinical care and research: the benefits and challenges of distance learning tools

Post Date:

2011-06-15

Publication:

Infectious Disease Clinics of North America

Expanding the capacity for clinical care and health research is a global priority and a global challenge. In disenfranchised communities facing the largest burden of disease, whether they be in rural Africa or in urban US, there is a great need for more well-trained, competent and dedicated...

QuantiFERON-TB Gold In-Tube for the detection of Mycobacterium tuberculosis infection in children with household tuberculosis contact

Post Date:

2011-05-05

Publication:

International Journal of Tuberculosis and Lung Disease

Setting : Improved strategies are needed for detecting Mycobacterium tuberculosis infection in children in TB-endemic settings. Objective : To determine the prevalence of M. tuberculosis infection by tuberculin skin testing (TST) and by the QuantiFERON-TB Gold In-Tube (...

Quantitative analysis of a urine-based assay for lipoarabinomannan in patients with tuberculosis

Post Date:

2010-08-15

Publication:

Journal of Clinical Microbiology

Abstract Urinary lipoarabinomannan (LAM) detection is a promising approach for rapid diagnosis of active tuberculosis (TB). In microbiologically confirmed TB patients, quantitative LAM detection results increased progressively with bacillary burden and immunosuppression. Patients with...

Publications - Disease diagnosis

Pages